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Controlled trial of aspirin in cerebral ischemia

An addendum

University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, TX.

Patients (303) who had had carotid territory transient ischemic attacks were randomly assigned to aspirin or placebo treatments. Patients with amaurosis fugax responded as well to aspirin as those with hemisphere events. Patients with lesions of the appropriate carotid artery responded better to aspirin therapy than patients with no lesion or an occlusion. The aspirin effect was the same across all risk-factor groups. Smoking had no effect on clinical outcome.

Address correspondence and reprint requests to Dr. Fields, Department of Neuro-Oncology. Box 118, The University of Texas M.D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, TX 77030.

This cooperative study was supported by NHLBI Grant No. HL-14340–03 to the Central Registry and separate grants to the participating institutions.

Accepted for publication September 27, 1985.

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