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Experimental spinal cord injury

Effects of trauma or ischemia on TRH and muscarinic receptors

Center for Neural Injury, San Francisco Veterans Administration Medical Center and the Department of Neurology, University of California at San Francisco. CA (Dr. Faden); and the Department of Pharmacology and Experimental Therapeutics (Drs. Pilotte and Burt). University of Maryland, School of Medicine. Baltimore, MD.

Traumatic spinal cord injury in rats and ischemic spinal cord injury in rabbits were associated with time-dependent, localized decreases in thyrotropin-releasing hormone (TRH) and muscarinic receptor binding. Changes were not evident in the first 24 to 48 hours, consistent with the hypothesis that secondary alterations in spinal cord may occur relatively late after injury. TRH receptor binding, but not muscarinic receptor binding, recovered by 3 weeks following trauma. Since TRH and acetylcholine may serve as excitatory neurotransmitters within the spinal cord, such changes could contribute to the functional neurologic impairment that follows injury.

Address correspondence and reprint requests to Dr. Faden, Neurology Service (127), San Francisco Veterans Administration Medical Center, 4150 Clement Street, San Francisco. CA 94121.

Supported in part by the Office of Naval Research (Contract No. N0001482WR20257).

Accepted for publication September 27, 1985.

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