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NEUROLOGY 1986;36:727
© 1986 American Academy of Neurology

Cerebrospinal fluid findings in healthy siblings of multiple sclerosis patients

Pierre Duquette, MD and Louise Charest, MSc

Hôpital Notre-Dame, Multiple Sclerosis Clinic, Montréal, Québec, Canada.

We studied six families in which two or more siblings were affected by MS. CSF analysis was available on 37 subjects: 9 with MS and 28 healthy siblings. Five of 28 healthy siblings (17.8%) had abnormal CSF immunoglobulins. These findings affect family studies of MS.

Address correspondence and reprint requests to Dr. Duquette, Hopital Notre-Dame, Case Postale 1560, Station C, Montréal, Québec, Canada H2L 4K8.

Accepted for publication October 1, 1985.




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