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NEUROLOGY 1986;36:772
© 1986 American Academy of Neurology

Familial Tourette's syndrome

Report of a large pedigree and potential for linkage analysis

Roger Kurlan, MD, Jill Behr, RN, MS, Louis Medved, MD, Ira Shoulson, MD, David Pauls, PhD, Judith R. Kidd, BA and Kenneth K. Kidd, PhD

Department of Neurology, University of Rochester School of Medicine, Rochester, NY, and the Department of Human Genetics. Yale University School of Medicine, New Haven, CT.

We studied a large Mennonite kindred affected by chronic motor tics (CMTs) and vocal tics in a probable autosomal dominant pattern. We administered a standardized questionnaire to 69 family members and reviewed our videotapes of 47. Using DSM III criteria and independent ratings, we diagnosed 10 subjects as having definite Tourette's syndrome (TS), 3 with definite CMTs, 15 with probable TS, and 1 with probable CMT. The clinical features of this family are presented. This is the largest known kindred with TS. Permanent lymphoblastoid cell lines have been established from 67 family members for genetic linkage analysis.

Address correspondence and reprint requests to Dr. Kurlan, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642.

Supported by the Tourette Syndrome Association, Bayside, NY (Dr. Kurlan), and USPHS Grants NS16648 and MH39239 (Dr. Kidd).

Accepted for publication October 17, 1985.




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