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Abnormal sensory evoked potentials in amyotrophic lateral sclerosis

Department of Medicine (Neurology), Duke University Medical Center, Durham, NC.

We have reviewed sensory evoked potential (EP) findings in 17 patients with amyotrophic lateral sclerosis (ALS). Somatosensory EPs were abnormal in 7 of 16 patients after lower-extremity stimulation and in 2 of 16 patients after upper-extremity stimulation. Brainstem auditory EP abnormalities were found in 2 of 12 patients. No abnormalities were noted on pattern reversal visual EPs in 12 patients. Overall, 47% of all ALS patients studied had at least one EP abnormality. EP evidence of CNS sensory dysfunction in ALS is more frequent than that noted clinically or pathologically and offers further support to previous observations of sensory system involvement in ALS.

Address correspondence and reprint requests to Dr. Radtke, Box 2905, Department of Medicine (Neurology), Duke University Medical Center. Durham, NC 27710.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Accepted for publication October 17, 1985.

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