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Unusual viral causes of transverse myelitis

Hepatitis A virus and cytomegalovirus

Department of Neurology (Drs. Tyler, Gross, and Cascino), Massachusetts General Hospital, and the Department of Microbiology and Molecular Genetics (Dr. Tyler), Harvard Medical School, Boston, MA. Dr. Gross is currently in the Dept. of Neurology, Univ. of Michigan Medical School, Ann Arbor, MI.

Twenty to 40% of cases of acute transverse myelitis are attributed to viral infections, although the specific viral etiology is only rarely identified. We studied two patients with transverse myelitis in association with acute hepatitis A virus (HAV) infection and acute primary cytomegalovirus (CMV) infection. This is the first well-documented report of an association between HAV infection and transverse myelitis, and only the fourth documented case of transverse myelitis in association with CMV infection in an immunoconepetent adult. Both viruses should be considered as rare causes of transverse myelitis in immunologically normal adults.

Address correspondence and reprint requests to Dr. Tyler, Department of Microbiology and Molecular Genetics, Harvard Medical School, D-1, Room 405, 25 Shattuck Street, Boston, MA 02115.

Dr. Tyler is supported by a physician-scientist grant from the National Institute of Allergy and Infectious Disease (5K11A100610) and by a fellowship grant from the Muscular Dystrophy Association. Research support has been provided by the William P. Anderson Foundation (Cincinnati, OH).

Accepted for publication October 10, 1985.

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