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Progressive polyradiculopathy in acquired immune deficiency syndrome

Department of Neurology (Dr. Eidelberg), Harvard Medical School and the Neurological Unit, and the Departments of Pathology (Drs. Sotrel, Vogel, and Walker). Radiology (Dr. Kleefield), and Medicine (Dr. Crumpacker), Beth Israel Hospital, Boston, MA.

We studied three patients with acquired immune defiency syndrome (AIDS) and progressive polyradiculopathy. Postmortem examination of one patient disclosed extensive necrosis, inflammatory infiltrates, and focal vasculitis of spinal roots. Typical cytomegaloviral (CMV), intranuclear, and intracytoplasmic inclusions were noted within enlarged endoneurial and endothelial cells. Progressive polyradiculopathy is an unusual complication of AIDS; CMV may be the causative agent in certain cases.

Address correspondence and reprint requests to Dr. Sotrel, Department of Pathology (Neuropathology), Beth Israel Hospital, 330 Brookline Ave., Boston. MA 02115.

Accepted for publication November 13, 1985.

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