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NEUROLOGY 1986;36:917
© 1986 American Academy of Neurology

The spectrum of neurologic disorder from vitamin E deficiency

Saty Satya-Murti, MD, Lyn Howard, MB, MRCP, Gregory Krohel, MD and Bruce Wolf, MS

Departments of Neurology (Drs. Satya-Murti and Krohel) and Ophthalmology (Dr. Krohel and Mr. Wolf), and the Division of Clinical Nutrition. Department of Medicine (Dr. Howard), Albany Medical College, Albany, NY.

We describe nine patients with fat malabsorption in whom a spectrum of vitamin E deficiency was present. Early deficiency was generally asymptomatic, and intermediate deficiency produced some impairment. Ataxia, weakness, reflex changes, impaired vision, and pigment retinopathy were associated with chronic, advanced deficiency. In the last group, delayed central somatosensory conduction and amplitude reduction of the electroretinogram were present. In adults, a severe vitamin E deficiency state existed for more than 5 years before producing measurable neurologic damage. The clinical picture is less homogeneous than previously suggested, and electrophysiologic abnormalities need not predate clinical dysfunction.

Address correspondence and reprint requests to Dr. Satya-Murti, Department of Neurology, Neil Hellman Research Building, Albany Medical College, Albany, NY 12208.

Supported in part by the Robert W. Graves Memorial Fund, Clinical Studies Center PHS Grant #5-MO-1-RR-000749–05, and the Oley Foundation for Parenteral and Enteral Nutrition.

Accepted for publication November 6, 1985.




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