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We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer's disease (AD) in seven Italian centers. One hundred sixteen hospital controls and 97 population controls were matched by age, sex, and region of residence to the cases. A structured questionnaire was administered to the next-of-kin of cases and controls by trained interviewers to identify possible risk factors. Genetic, viral, toxic, immunologic, medical, surgical, and personality factors were investigated. Dementia among first- or second-degree relatives and advanced age of the mother at subject's birth (age over 40) were associated with AD. Head trauma was more frequent in cases than in either hospital or population controls, but the differences were not significant. Our data did not confirm the previously reported association with antecedent thyroid disease or family history of Down's syndrome.
Address correspondence and reprint requests to Dr. Rocca, Neuroepidemiology Branch, NINCDS, NIH, Room 804, Federal Building, 7550 Wisconsin Avenue, Bethesda, MD 20892.
For the Study Group Participants, see Appendix.
Supported in part by the Italian National Research Council (CNR)—Grant no. 840221156, and carried out under the auspices of the Science and Technology Bilateral Agreement between Italy and the United States.
Accepted for publication November 21, 1985.
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