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Neuromuscular Research Unit, Department of Neurology, Tufts-New England Medical Center, Boston, MA.
Reliable measurements are needed to document the natural history of ALS and to determine therapeutic efficacy. We have devised a standardized protocol that generates interval data sensitive to change—the Tufts Quantitative Neuromuscular Exam (TQNE). The TQNE consists of the following four major categories: pulmonary function, oropharyngeal function, timed functional activities, and isometric strength using an electronic strain gauge. The 29-item exam takes about 1 hour to administer and has excellent test-retest reliability.
Address correspondence and reprint requests to Ms. Andres, Neuromuscular Research Unit, Department of Neurology, Tufts-New England Medical Center, Boston, MA 02111.
Funded by grants from the Muscular Dystrophy Association and NIH Grant CRC #MO1RR000054.
Accepted for publication November 19, 1985.
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