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NEUROLOGY 1986;36:948
© 1986 American Academy of Neurology

Amyotrophic lateral sclerosis

Histologic, histochemical, and ultrastructural abnormalities of skin

Seiitsu Ono, MD, Yasuo Toyokura, MD, Toru Mannen, MD and Yasumasa Ishibashi, MD

Department of Neurology (Drs. Ono and Mannen), Institute of Brain Research, and Department of Dermatology (Dr. Ishibashi), Faculty of Medicine, University of Tokyo; and the Department of Neurology (Dr. Toyokura), Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

We studied the reticular dermis in patients with amyotrophic lateral sclerosis (ALS) and controls with or without neurologic diseases. By light microscopy, collagen bundles in ALS dermis were reduced in amount and more loosely woven than in controls. Electronmicroscopy revealed a significant negative correlation between duration of illness and the diameter of collagen fibrils in patients with ALS. There was also a marked increase of amorphous material positive for ruthenium red in the ground substance. These findings were not observed in controls.

Address correspondence and reprint requests to Dr. Ono, Department of Neurology, Institute of Brain Research, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113, Japan.

Accepted for publication November 7, 1985.




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