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Departments of Neurology (Dr. Rodriguez) and Immunology (Drs. Rodriguez, Lafuse, and David), Mayo Clinic and Mayo Foundation, Rochester, MN; and the Department of Pathology (Dr. Leibowitz), University of Texas Medical School at Houston, TX.
In vivo administration of monoclonal antibody reactive with major histocompatibility complex-encoded Ia molecules (I-A8) partially suppressed inflammation and demyelination in the spinal cord of SJL/J (H-28) mice persistently infected with Theiler's murine encephalomyelitis virus. Demyelination was decreased if antibody was given at the time of virus inoculation or after inflammation had been established in the spinal cord. The decrease in demyelination was independent of isolation of infectious virus from the CNS or of serum titers of immunoglobulin to purified viral antigen. Thus, Theiler's virus-induced demyelination is mediated, in part, by immune cells that carry Ia class II molecules.
Address correspondence and reprint requests to Dr. Rodriguez, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.
Moses Rodriguez is the recipient of a Teacher-Investigator Award (NS-00849) from the National Institutes of Health and is a Rappaport Scholar of the Mayo Clinic and Mayo Foundation.
Accepted for publication November 13, 1985.
This article has been cited by other articles:
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X. Lin, M. K. Njenga, A. J. Johnson, K. D. Pavelko, C. S. David, L. R. Pease, and M. Rodriguez Transgenic Expression of Theiler's Murine Encephalomyelitis Virus Genes in H-2b Mice Inhibits Resistance to Virus-Induced Demyelination J. Virol., June 27, 2002; 76(15): 7799 - 7811. [Abstract] [Full Text] [PDF]
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K. L. Neville, M. C. Dal Canto, J. A. Bluestone, and S. D. Miller CD28 Costimulatory Blockade Exacerbates Disease Severity and Accelerates Epitope Spreading in a Virus-Induced Autoimmune Disease J. Virol., September 15, 2000; 74(18): 8349 - 8357. [Abstract] [Full Text]
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 K. M. Drescher, P. D. Murray, X. Lin, J. A. Carlino, and M. Rodriguez TGF-{beta}2 Reduces Demyelination, Virus Antigen Expression, and Macrophage Recruitment in a Viral Model of Multiple Sclerosis J. Immunol., March 15, 2000; 164(6): 3207 - 3213. [Abstract] [Full Text] [PDF]
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 K. M. Drescher, S. L. Johnston, W. Hogancamp, G. H. Nabozny, C. S. David, I. J. Rimm, P. J. Wettstein, and M. Rodriguez V{beta}8+ T cells protect from demyelinating disease in a viral model of multiple sclerosis Int. Immunol., March 1, 2000; 12(3): 271 - 280. [Abstract] [Full Text] [PDF]
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J. P. Palma, R. L. Yauch, S. Lang, and B. S. Kim Potential Role of CD4+ T Cell-Mediated Apoptosis of Activated Astrocytes in Theiler's Virus-Induced Demyelination J. Immunol., June 1, 1999; 162(11): 6543 - 6551. [Abstract] [Full Text] [PDF]
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I. J. McCright, I. Tsunoda, F. G. Whitby, and R. S. Fujinami Theiler's Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis J. Virol., April 1, 1999; 73(4): 2814 - 2824. [Abstract] [Full Text]
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A. Inoue, C.-S. Koh, M. Yamazaki, H. Yahikozawa, M. Ichikawa, H. Yagita, and B. S. Kim Suppressive Effect on Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease by the Administration of Anti-IL-12 Antibody J. Immunol., November 15, 1998; 161(10): 5586 - 5593. [Abstract] [Full Text] [PDF]
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P. D. Murray, K. D. Pavelko, J. Leibowitz, X. Lin, and M. Rodriguez CD4+ and CD8+ T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis J. Virol., September 1, 1998; 72(9): 7320 - 7329. [Abstract] [Full Text] [PDF]
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 J.-F. Bureau, K. M. Drescher, L. R. Pease, T. Vikoren, M. Delcroix, L. Zoecklein, M. Brahic, and M. Rodriguez Chromosome 14 Contains Determinants That Regulate Susceptibility to Theiler's Virus–Induced Demyelination in the Mouse Genetics, April 1, 1998; 148(4): 1941 - 1949. [Abstract] [Full Text] [PDF]
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B. S. Kim, R. L. Yauch, Y. Y. Bahk, J.-A. Kang, M. C. Dal Canto, and C. K. Hall A Spontaneous Low-Pathogenic Variant of Theiler's Virus Contains an Amino Acid Substitution within the Predominant VP1233-250 T-Cell Epitope J. Virol., February 1, 1998; 72(2): 1020 - 1027. [Abstract] [Full Text] [PDF]
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 R. C. Woody, R. W. Steele, R. K. Charlton, and V. Smith Histocompatibility Determinants in Childhood Postinfectious Encephalomyelitis J Child Neurol, July 1, 1989; 4(3): 204 - 207. [Abstract] [PDF]
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