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NEUROLOGY 1986;36:971
© 1986 American Academy of Neurology

Monoamine neurotransmitters in diffuse reversible forebrain ischemia and early recirculation

Increased dopaminergic activity

Sami I. Harik, MD, Shinichi Yoshida, MD, Raul Busto, BS and Myron D. Ginsberg, MD

Department of Neurology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH; and the Cerebral Vascular Disease Research Center and the Department of Neurology, University of Miami School of Medicine, Miami, FL.

Regional levels of brain monoamines and their metabolites were examined in a rat model of reversible and diffuse forebrain ischemia with and without reperfusion. During ischemia, blood flow decreased by 87 to 95%, but recovered to control values during recirculation. Norepinephrine and serotonin decreased in the cerebral cortex and hippocampus during ischemia and diminished further during recirculation. On the other hand, dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, which were not much affected by ischemia, increased markedly in the cerebral cortex and striatum during recirculation, with a decrease in the ratio of dopamine to its metabolites. These results suggest central dopaminergic hyperactivity during recirculation, which may be related to the selective vulnerability of the striatum in similar models of reversible forebrain ischemia.

Address correspondence and reprint requests to Dr. Harik. Department of Neurology, University Hospitals of Cleveland, Cleveland, OH 44106.

Supported by the David S. Ingalls Neurological Institute at University Hospitals of Cleveland, USPHS grants NS-05820 and NS-18150. Dr. Ginsberg is recipient of a Jacob Javits Neuroscience Investigator Award, NINCDS.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Accepted for publication November 6, 1985.






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