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NEUROLOGY 1986;36:984
© 1986 American Academy of Neurology

Therapeutic experience with transdihydrolisuride in Huntington's disease

Sirio Bassi, MD, Maria Grazia Albizzati, MD, Gian Umberto Corsini, MD, Lodovico Frattola, MD, Roberto Piolti, MD, Irmgard Suchy, MD and Marco Trabucchi, MD

Neurological Clinic (Drs. Bassi, Albizzati, Frattola, and Piolti), University of Milan; Clinical Pharmacology (Dr. Corsini), University of Cagliari, Italy; Department of Neuroendocrinology and Neuropsychopharmacology (Dr. Suchy), Schering AG, Berlin, West Germany; and the Chair of Toxicology (Dr. Trabucchi), University of Rome, Italy.

Transdihydrolisuride is an ergot derivative with mixed agonist and antagonist effects on central dopamine receptors. We gave the drug orally (1 mg daily) to 10 patients with Huntington's disease. In seven patients, the chorea improved with no adverse effects during the study.

Address correspondence and reprint requests to Dr. Frattola, Neurological Clinic, Ospedale San Gerardo, Via Donizetti 106, 20052 Monza, Italy.

Accepted for publication October 14, 1985.






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