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Tobacco intolerance in multiple system atrophy

Department of Neurology, Northwestern University Medical School, and the Veterans Administration Lakeside Medical Center, Chicago, IL.

In a patient with multiple system atrophy, the ataxia was temporarily exacerbated by cigarette smoking. The phenomenon is attributed to a direct effect of nicotine on the central nervous system, rather than being secondary to autonomic changes. Its prevalence and specificity are currently unknown.

Address correspondence and reprint requests to Dr. Miller, Northwestern University, Department of Neurology, 303 East Chicago Avenue, Chicago, IL 60611.

Accepted for publication October 31, 1985.

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