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NEUROLOGY 1986;36:993
© 1986 American Academy of Neurology

Double-blind assessment of potential pergolide-induced cardiotoxicity

Roger Kurlan, MD, Charlyne Miller, RN, MS, Robert Knapp, MD, Gerald Murphy, MD and Ira Shoulson, MD

Departments of Neurology and Cardiology (Dr. Murphy), University of Rochester School of Medicine, Rochester, NY.

Possible pergolide-induced cardiotoxicity has been reported in open trials. Over a 6-month period of observation, we prospectively analyzed ECGs and 24-hour ambulatory ECG in 23 patients with Parkinson's disease who were randomized in a double-blind fashion to pergolide or placebo treatments. Pergolide therapy was associated with a mild and transient bradycardiac effect, but no clinically significant cardiotoxicity.

Address correspondence and reprint requests to Dr. Kurlan, University of Rochester Medical Center, 601 Elmwood Avenue, Box 673, Rochester, NY 14642.

Supported by a United Parkinson Foundation fellowship (Dr. Kurlan), USPHS grant RR00044 (University of Rochester Clinical Research Center), and Eli Lilly Company.

Accepted for publication November 19, 1985.




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