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© 1986 American Academy of Neurology Localization and quantification of beta-adrenergic receptors in human brainDepartments of Pharmacology (Mr. Reznikoff and Drs. Winokur and Rainbow) and Psychiatry (Drs. Manaker and Winokur), and the Division of Neuropathology (Dr. Rhodes), School of Medicine, University of Pennsylvania, Philadelphia, PA. Little information is currently available on the localization of noradrenergic systems in the human CNS. We used quantitative autoradiography with [125I] iodopindolol to examine beta-adrenergic receptors in postmortem human brain. The concentration of beta-receptors was highest in all subfields of the hippocampus, followed by cerebellum, and then thalamic nuclei, basal ganglia, midbrain, and cerebral cortex. Low levels were found in white matter and hypothalamus. This distribution differed from the distribution of beta-receptors reported in membrane homogenates of human brain and also from the distribution of beta-receptors in rat brain determined by autoradiography. The similarities and differences between the distribution of beta-receptors in the human and rat brains may have implications regarding the role of norepinephrine in the CNS of these two species. Address correspondence and reprint requests to Dr. Manaker, Department of Pharmacology/G3, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. Supported by NIH NS19597 and NS20006, the United Parkinson Fund, and Esther A. and Joseph Klingenstein and Alfred P. Sloan fellowships to T.C.R., who was an Established Investigator of the American Heart Association. S.M. was supported by Medical Scientist Training Program NIH 5T32 GM 07170, and C.H.R. was supported in part by 2T32 NS07064. Accepted for publication December 18, 1985.
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