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PET before and after surgery for tumor-induced parkinsonism

MRC Cyclotron Unit and Department of Neurology (Dr. Leenders), Hammersmith Hospital, London, UK; the Regional Centre for Neurology and Neurosurgery (Drs. Findley and Cleeves). Oldchurch Hospital, Essex, UK; and the MRC Neuro-Otology Unit, National Hospital for Nervous Diseases, London, UK.

We studied a patient with left frontal meningioma and right-sided parkinsonism that resolved completely after operation. PET scans were performed before and after operation to measure regional cerebral blood flow, oxygen extraction ratio, oxygen utilization, and blood volume. A specific pattern of severe functional changes returned to normal postoperatively. The data suggest increased local tissue pressure due to edema, causing a functional disorder in the left basal ganglia that gave rise to reversible contralateral parkinsonism.

Address correspondence and reprint requests to Dr. Leenders, MRC Cyclotron Unit and Department of Neurology, Hammersmith Hospital, Du Cane Road, London W12, UK.

Accepted for publication December 18, 1985.

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