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The effects of pregnancy in multiple sclerosis

A retrospective study

Center for Neurological Diseases/Rocky Mountain Multiple Sclerosis Center, Department of Neurology, University of Colorado School of Medicine, and the Veterans Administration Medical Center, Denver, CO.

We reviewed the medical records of 178 women with multiple sclerosis to evaluate the number of completed pregnancies, current disability status, and relationship of pregnancy to onset of MS symptoms. We found no differences in the long-term disability of women with no pregnancies, one pregnancy, or two or more pregnancies. Women who had initial symptom onset in pregnancy experienced less subsequent disability than women whose symptoms began before or after pregnancy. Therefore, pregnancy per se or number of pregnancies has no effect on subsequent disability.

Address correspondence and reprint requests to Dr. Franklin, Rocky Mountain Multiple Sclerosis Center, Box B181, 4200 East 9th Avenue, University of Colorado School of Medicine, Denver, CO 80262.

Supported in part by a grant from the Multiple Sclerosis Society of Colorado.

Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA. April 1984.

Accepted for publication December 18, 1985.

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