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NMR studies in experimental allergic encephalomyelitis (EAE)

Normalization of T₁ and T₂ with parenchymal cellular infiltration

Departments of Diagnostic Radiology and Nuclear Medicine (Dr. Karlik), Clinical Neurological Sciences (Drs. Karlik, Gilbert, and Noseworthy), Pathology (Drs. Karlik and Gilbert), and Microbiology and Immunology (Dr. Strejan), University of Western Ontario, London. Ontario, Canada.

The central nervous system (CNS) of guinea pigs undergoing acute experimental allergic encephalomyelitis (EAE) induced by whole CNS shows a characteristic progression of proton NMR relaxation times that correlates with pathologic features of the disease. Specifically, T₁ was prolonged during meningeal infiltration and perivascular inflammation. T₂ was increased with demyelination. Both proton T₁ and T₂ values, however, were normalized in active lesions containing an extensive cellular response (encephalitis, myelitis).

Address correspondence and reprint requests to Dr. Karlik, Department of Diagnostic Radiology, University Hospital, PO Box 5339, Postal Station "A", London, Ontario, Canada N6A 5A5.

Supported by grants from the Physicians Services Incorporated Foundation and the University Hospital Pooled Research Fund.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, May 1985.

Accepted for publication December 18, 1985.

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