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Glucose and perinatal hypoxic-ischemic brain damage in the rat

Departments of Pediatrics (Pediatric Neurology) and Pathology (Neuropatholugy). Cornell University Medical College-New York Hospital, New York. NY.

Seven-day postnatal rats were rendered hyperglycemic by the SC injection of 50% glucose, following which they were exposed to hypoxia with 8% oxygen. The glucose-treated animals survived more than twice as long as saline-treated littermates. Other hyperglycemic and control rat pups were subjected to hypoxia-ischemia by unilateral common carotid artery occlusion combined with 2 hours of hypoxia. Neuropathologic analysis of recovered animals at 30 days of age showed that the brains of the glucose-treated animals were no more damaged than those of the saline controls (p > 0.05). The finding indicates that, unlike adults, glucose supplementation and its associated hyperglycemia in the immature rat does not increase the extent of hypoxic-ischemic brain damage.

Address correspondence and reprint requests to Dr. Vannucci, Department of Pediatrics. Milton S. Hershey Medical Center. Pennsylvania State University. PO Box 850, Hershey, PA 17033.

Supported in part by Grant No. 1 R01 HD 15738 from the National Institutes of Health (Dr. Vannucci). Dr. Voorhies is the recipient of a National Research Service Award (1 F32 NS 07023) from the National Institutes of Health.

Presented in part at the thirty-fourth annual meeting of the American Academy of Neurology. Washington, DC, April 1982.

Accepted for publication December 18, 1985.

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