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Effect of L-dopa on visual evoked potential in patients with Parkinson's disease

Departments of Neurology (Drs Bhaskar. Vanchilingam, Devaprabhu, and Ganesan) and Pharmacology (Dr. E.A. Bhaskar), Medical College and Hospital, Thanjavur, India.

In 47 patients with Parkinson's disease, we studied the visual evoked potential (VEP) using the pattern-reversal checkerboard (CBVEP) and the grating (GVEP) stimuli before and after 3 months of L-dopa therapy. The P100 latency in both CBVEP and GVEP was prolonged before L-dopa therapy, usually commensurate with the degree of motor disability. Clinical improvement of the parkinsonian state after L-dopa therapy was associated with shortening of the P100 latency in CBVEP, but not significantly in GVEP.

Address correspondence and reprint requests to Dr. P.A. Bhaskar, Department of Neurology, Medical College Hospital, Thanjavur 613 004, South India.

Accepted for publication December 18, 1985.

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