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Contrast sensitivity in Parkinson's disease

Departments of Neurology, Sint Franciscus Gasthuis (Dr. Bulens) and University Hospital Dijkzigt (Dr. Meerwaldt); and the Department of Biological and Medical Physics (Dr. van der Wildt and C.J. Keemink), Erasmus University, Rotterdam. The Netherlands.

We studied contrast-sensitivity function in 39 patients with Parkinson's disease. Sixty-four percent of the patients showed contrast-sensitivity loss in one or both eyes. The abnormality was not related to the first symptom or the severity of disease. Sensitivity loss at intermediate frequencies (notch loss) in 30% of the "affected" eyes suggested a cortical component. These findings support the belief that there is a widespread neurotransmitter deficiency in Parkinson's disease.

Address correspondence and reprint requests to Dr. Bulens, Department of Neurology, Sint Franciscus Gasthuis, Postbus 10900, 3004 BA Rotterdam, The Netherlands.

Accepted for publication December 18, 1985.

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