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NEUROLOGY 1986;36:1163
© 1986 American Academy of Neurology

Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration

Julie Cunningham, PhD, Francesc Graus, MD, Neil Anderson, MB, ChB and Jerome B. Posner, MD

Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.

Serum from seven patients with paraneoplastic cerebellar degeneration contained anti-Purkinje cell antibodies. The samples were examined by immunoblotting to determine whether they recognized common antigens in isolated human Purkinje cell neurons. Two groups of antigens were detected by all seven sera with Mr 62/64 kd and 34 to 38 kd, both of which contributed to the Purkinje cell antigens detected immunohistochemically. These reactivities were absent from all controls tested. These antibodies may play a role in the pathogenesis of paraneoplastic cerebellar degeneration.

Address correspondence and reprint requests to Dr. Posner, Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Dr. Anderson is supported in part by the New Zealand Neurological Foundation.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Accepted for publication February 4, 1986.




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