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NEUROLOGY 1986;36:1169
© 1986 American Academy of Neurology

Antibodies to brain proteins in paraneoplastic cerebellar degeneration

Keiko Tanaka, MD, Motoyoshi Yamazaki, MD, Shuzo Sato, MD, Itaru Toyoshima, MD, Akio Yamamoto, MD and Tadashi Miyatake, MD

Departments of Neurology (Drs. Tanaka, Yamazaki, Sato, Toyoshima, and Miyatake) and Neurochemistry (Dr. Yamamoto), Brain Research Institute, Niigata University, Niigata. Japan.

A 68-year-old man had subacute cerebellar degeneration and a non-Hodgkin's lymphoma. Using an immunoblotting method, we found serum antibodies to rat cerebral 250-kd and 110-kd and cerebellar 110-kd acidic cytoplasmic proteins. The antibodies did not react unless the antigens were prepared soon after death with protease inhibitors. Two hundred fifty-kd and 110-kd proteins are minor components of soluble cytoplasmic proteins of the brain. The molecular weights differed from other soluble brain-specific proteins already characterized.

Address correspondence and reprint requests to Dr. Tanaka, Department of Neurology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata City, Japan 951.

Accepted for publication January 13, 1986.




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