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Sergievsky Center (Dr. Hauser), Columbia University, New York, NY; and the Department of Psychiatry (Dr. Heston) and the Dight Institute of Human Genetics (Drs. Morris and Anderson), University of Minnesota, Minneapolis: MN.
We reviewed 81 patients with dementia and autopsy findings of Alzheimer's disease (AD) to identify patients with seizures or myoclonus after onset of dementia. Eight (10%) had seizures, and eight others (10%) had myoclonus. The incidence of seizures was 10 times more than expected in a reference population. Seizures occurred in any stage of AD, but myoclonus was often a late manifestation. Both seizures and myoclonus, individually or together, are manifestations of AD and may be seen at any time in the course of the illness.
Address correspondence and reprint requests to Dr. Hauser, Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032.
Supported in part by the Minnesota Comprehensive Epilepsy Program, 1P50-NS-16308.
Accepted for publication January 13, 1986.
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