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NEUROLOGY 1986;36:1230
© 1986 American Academy of Neurology

Multisystem degeneration

Drugs and square wave jerks

Toshiyuki Fukazawa, MD, Kunio Tashiro, MD, Takeshi Hamada, MD and Manabu Kase, MD

Division of Neurology, Department of Neurosurgery (Drs. Fukazawa and Tashiro) and Department of Ophthalmology (Dr. Kase), Hokkaido University School of Medicine, and the Hokuyukai Neurological Hospital (Dr. Hamada), Sapporo, Japan.

We studied a 55-year-old woman with macrosquare wave jerks and macrosaccadic oscillations with a vertical component. The oscillations almost completely disappeared after administration of diazepam, clonazepam, thiamylal, or phenobarbital. A disorder of GABAergic tonic inhibitory system from the substantia nigra to superior colliculus probably plays an important role in the pathogenesis of these abnormal ocular movements.

Address correspondence and reprint requests to Dr. Fukazawa, Division of Neurology, Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo 060, Japan.

Accepted for publication January 13, 1986.




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