HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chad, D. A. Articles by Sargent, J. Search for Related Content PubMed PubMed Citation Articles by Chad, D. A. Articles by Sargent, J.

Slow resolution of multifocal weakness and fasciculation

A reversible motor neuron syndrome

Department of Neurology, University of Massachusetts, Worcester, MA.

A 25-year-old man with multifocal weakness and fasciculation was thought to have motor neuron disease. Signs progressed for 1 year, plateaued, and 3 years later resolved almost completely. There was no evidence of paraproteinemia, lymphoproliferative disorder, or vasculitis, and myelography was normal. Electrodiagnostic study disclosed multifocal, acute and chronic denervation that evolved into a picture consistent with residuals of old multifocal radiculopathy without active denervation. Prolongation of F response, absence of H-reflex, and conduction block in a proximal nerve segment suggested multifocal demyelination. A proximal motor neuropathy, perhaps demyelinating, may cause some of the benign motor neuron syndromes that simulate motor neuron disease.

Address correspondence and reprint requests to Dr. Chad, Department of Neurology, University of Massachusetts, 55 Lake Avenue North, Worcester, MA 01605.

Accepted for publication December 27, 1985.

This article has been cited by other articles:

				Y A Rajabally Multifocal motor neuropathy: review of a treatable immune mediated disorder Postgrad. Med. J., June 1, 2008; 84(992): 287 - 292. [Abstract] [Full Text] [PDF]

				J-M Leger, K Viala, F Cancalon, T Maisonobe, B Gruwez, T Waegemans, and P Bouche Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg and of its predictive criteria in 40 patients J. Neurol. Neurosurg. Psychiatry, January 1, 2008; 79(1): 93 - 96. [Abstract] [Full Text] [PDF]

				A Ghosh, M Busby, R Kennett, K Mills, and M Donaghy A practical definition of conduction block in IvIg responsive multifocal motor neuropathy J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(9): 1264 - 1268. [Abstract] [Full Text] [PDF]

				R Arunachalam, A Osei-Lah, and K R Mills Transcutaneous cervical root stimulation in the diagnosis of multifocal motor neuropathy with conduction block J. Neurol. Neurosurg. Psychiatry, September 1, 2003; 74(9): 1329 - 1331. [Abstract] [Full Text] [PDF]

				A. Priori, C. Cinnante, A. Pesenti, M. Carpo, A. Cappellari, E. Nobile-Orazio, G. Scarlato, and S. Barbieri Distinctive abnormalities of motor axonal strength-duration properties in multifocal motor neuropathy and in motor neurone disease Brain, November 1, 2002; 125(11): 2481 - 2490. [Abstract] [Full Text] [PDF]

				N. Meucci, A. Cappellari, S. Barbieri, G. Scarlato, and E. Nobile-Orazio Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy J. Neurol. Neurosurg. Psychiatry, December 1, 1997; 63(6): 765 - 769. [Abstract] [Full Text] [PDF]

				H. Mitsumoto, M. R. Hanson, and D. A. Chad Amyotrophic Lateral Sclerosis: Recent Advances in Pathogenesis and Therapeutic Trials Arch Neurol, February 1, 1988; 45(2): 189 - 202. [Abstract] [PDF]