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NEUROLOGY 1987;37:364
© 1987 American Academy of Neurology

Saccades in Huntington's disease

Initiation defects and distractibility

A. G. Lasker, MS, D. S. Zee, MD, T. C. Hain, MD, S. E. Folstein, MD and H. S. Singer, MD

Departments of' Ophthalmology, Neurology, Neuroscience, and Psychiatry, Johns Hopkins University, School of Medicine, Baltimme, MD.

We recorded saccadic eye movements in patients mildly affected with Huntington's disease. Most showed an increase in saccade latencies that was greater for saccades made on command than to the sudden appearance of a visual target. All patients showed excessive distractibility during attempted fixation. They had particular difficulty suppressing a saccade to a suddenly appearing visual target when simultaneously trying to initiate a saccade in the opposite direction. Our results are compatible with a posited role of the basal ganglia in both the initiation of volitional saccades and in the maintenance of fixation. Saccade abnormalitie—especially distractibility—are sensitive but probably not specific indicators of Huntington's disease.

Address correspondence and reprint requests to Mr. Lasker, Wilmer Eye Institute, Woods 355, Johns Hopkins Hospital, Baltimore, MD 21205.

Received April 28, 1986. Accepted for publication in final form July 2, 1986.

Supported by NIH grant 2PO1 NS 16375.




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