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Fine analysis of cytolytic and natural killer T lymphocytes in the CSF in multiple sclerosis and other neurologic diseases

Department of Immunology (Drs. Weber and Raus and Mr. Vandermeeren), Dr. L. Willemsinstituut, University Campus, Diepenbeek, Belgium; the Department of Surgery (Dr. Buurman), Academic Hospital Maastricht, University Limburg, Maastricht, The Netherlands; and the Multiple Sclerosis and Rehabilitation Clinic (Dr. Medaer), Overpelt, Belgium.

Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were higher in patients with OND of inflammatory nature than in patients with noninflammatory OND. In all MS patients, these frequencies were higher in the CSF than in their peripheral blood. Surprisingly, in all patients studied, the CSF contained a substantial number of CTL-p with a helper (CD4 +) phenotype.

Address correspondence and reprint requests to Dr. Weber, Department of Immunology, Dr. L. Willemsinstituut, Universitaire Campus, 3610 Diepenbeek, Belgium.

Supported by W.O.M.S. Belgium and the "Nationale Loterij," Belgium.

Received March 25, 1986. Accepted for publication in final form June 23, 1986.

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