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A clinical and autopsy study of dementia in Olmsted County, Minnesota, 1980–1981

Department of Neurology (Dr. Kokmen) and the Sections of Medical Pathology (Dr. Okazaki) and Medical Research Statistics (Mr. Offord), Mayo Clinic and Mayo Foundation, Rochester, MN.

The clinical records and autopsy protocols were studied from 350 cases in which an autopsy was done in Olmsted County, MN, in 1980 and 1981. Overall autopsy rate was 33.6%, and autopsy rate for those aged 60 years or more was 29%. Preselected criteria were used for diagnosis of dementia. Thirty-two demented and 68 nondemented patients had complete autopsies; all were more than 60 years old. Twenty-three of 32 (72%) demented patients had Alzheimer's disease. The frequency of cerebral infarcts among the nondemented patients was significantly higher than among the demented patients (p = 0.02).

Address correspondence and reprint requests to Dr. Kokmen, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Received December 23, 1985. Accepted for publication in final form June 24, 1986.

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