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Positron emission tomography and histopathology in Pick's disease

Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.

PET using ¹⁸F-2-fluoro-2-deoxyglucose was carried out on a case of Pick's disease established by necropsy. A sharply decreased cortical metabolic rate for glucose was obtained in specific gyri, especially in the frontal lobes, where there was extensive gliosis and neuronal loss. More moderate decreases were found in areas with numerous Pick bodies and inflated neurons but less gliosis. The PET pattern was sufficiently distinctive to suggest that it might be possible to distinguish Pick's from Alzheimer's disease premortem.

Address correspondence and reprint requests to Dr. P.L. McGeer, University of British Columbia, Kinsmen Laboratory of Neurological Research, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1W5.

Supported by two program grants from the Medical Research Council of Canada and grants from the Mr. and Mrs. P.A. Woodward's Foundation, the B.C. Medical Services Foundation. and the Alzheimer's Society of British Columbia.

Received May 5, 1986. Accepted for publication in final form July 2, 1986.

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