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Kinetic predominant essential tremor

Successful treatment with clonazepam

Department of Neurology (Dr. Biary), University of Illinois at Chicago, and the Department of Neurology (Dr. Koller), Loyola-Hines Medical Center, Chicago, IL.

Fourteen patients with marked kinetic tremors of long duration but no other major neurologic signs are described. A positive family history of essential tremor, mild postural tremor, and tremor suppression with alcohol suggest that the condition is a variant of essential tremor. Kinetic tremors had a frequency of 3.5 to 6.0 Hz and an alternating EMG pattern. Propranolol caused improvement in some patients, but clonazepam treatment resulted in tremor suppression in all patients. Kinetic tremor without cerebellar signs is a subtype of essential tremor with pharmacologic responsiveness to clonazepam.

Address correspondence and reprint requests to Dr. Biary, Department of Neurology, University of Illinois at Chicago, 912 South Wood Street, Chicago, IL 60612.

Received March 18, 1986. Accepted for publication in final form June 24, 1986.

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