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NEUROLOGY 1987;37:570
© 1987 American Academy of Neurology

Progressive supranuclear palsy and a multi-infarct state

Richard M. Dubinsky, MD and Joseph Jankovic, MD

Baylor College of Medicine, Department of Neurology, Houston, TX.

In 58 patients with progressive supranuclear palsy (PSP), 19 (32.8%) had CT, MRI, or autopsy evidence of a multi-infarct (MI) state. The clinical findings in the infarct syndrome were similar to idiopathic PSP. Five MI-PSP patients had had a stroke, four had focal dystonia, two had hemiparesis, and one had an intention tremor of recent onset. In contrast, only 5.9% (12.9% of those with CT or MRI) of 426 Parkinson's disease patients had evidence of strokes. One case of PSP studied pathologically was attributed to cerebral amyloid angiopathy.

Address correspondence and reprint requests to Dr. Jankovic, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received May 27, 1986. Accepted for publication in final form August 6, 1986.




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