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Glucose utilization rate versus brain size in humans

Neuroimaging Section, NINCDS (Drs. Hatazawa, Brooks, and Di Chiro) and the Nuclear Medicine Department, Clinical Center (Dr. Bacharach), National Institutes of Health, Bethesda, MD.

Cerebral glucose metabolic rates were measured in 23 normal volunteers by studying the uptake of ¹⁸F-deoxyglucose with positron emission tomography (PET). These values were correlated against a brain-size index obtained from the PET images by measuring the lateral and anteroposterior brain diameters. There was a significant negative correlation (p < 0.001), which corresponds, within the statistical uncertainty, to an inverse proportionality of glucose metabolic rate and brain volume. The variation with brain size accounted for approximately one-half of the total intersubject variance. Measurements on phantoms of different sizes and analyses of instrumental errors failed to uncover any artifactual reason for the correlation.

Address correspondence and reprint requests to Dr. Di Chiro, National Institutes of Health, Building 10, Room 1C451, Bethesda, MD 20892.

Received April 25, 1986. Accepted for publication in final form July 18, 1986.