Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Glass, J. P.
Right arrow Articles by Holmes, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glass, J. P.
Right arrow Articles by Holmes, R.
NEUROLOGY 1987;37:639
© 1987 American Academy of Neurology

Central nervous system complications of a newly recognized subtype of leukemia

AMML with a pericentric inversion of chromosome 16

J. P. Glass, MD, P. Van Tassel, MD, M. J. Keating, MBBS, A. Cork, MA, J. Trujillo, MD and R. Holmes, MBBS

Departments of Neuro-Oncology (Dr. Glass), Diagnostic Radiology (Dr. Van Tassel), Hematology (Drs. Keating and Holmes), and Laboratory Medicine (Ms. Cork and Dr. Trujillo), The University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX.

Ten patients with acute myelomonocytic leukemia (AMML) and inversion of chromosome 16 who had CNS involvement were identified at M.D. Anderson Hospital between January 1972 and December 1984. The nervous system signs and symptoms were evaluated in detail. CT scans, CSF cytologies, and treatment modalities were reviewed. Two patients underwent biopsies of lesions that proved to be granulocytic sarcomas. AMML with inversion 16 carries a much higher (33%) incidence of CNS involvement in the form of leptomeningeal metastasis and/or granulocytic sarcoma than all other acute nonlymphocytic leukemias (5%). The reason for this appears to be related to the chromosomal aberration and not to prolonged survival.

Address correspondence and reprint requests to Dr. Glass, M.D. Anderson Hospital and Tumor Institute, Department of Neuro-Oncology, Box 118, 6723 Bertner Avenue, Houston, TX 77030.

Received March 28, 1986. Accepted for publication in final form July 18, 1986.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by AAN Enterprises, Inc.