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Comparison of Duchenne and normal myoblasts from a heterozygote

Johns Hopkins University, School of Medicine (Dr. Hurko, Ms. McKee, and Dr. Zuurveld), Baltimore, MD; and the Medical College of Wisconsin (Dr. Swick), Milwaukee, WI.

To test the hypothesis that the Duchenne muscular dystrophy gene limits the proliferation of myoblasts, we studied myoblasts from a woman who was a carrier of the Duchenne gene and also heterozygous for glucose-6-phosphate dehydrogenase (G6PD), an X-linked enzyme. G6PD-A and G6PD-B cells did not differ in proliferative capacity, implying no difference in proliferative capacity of cells bearing the Duchenne gene or the normal allele.

Address correspondence and reprint requests to Dr. Hurko, Department of Neurology, Meyer 6–119, The Johns Hopkins University, School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205.

Supported by a grant from the Muscular Dystrophy Association.

This work was presented as a poster at a UCLA symposium at Park City, UT, March 1985,³⁹ and presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.⁴¹

Received April 18, 1986. Accepted for publication in final form August 5, 1986.