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NEUROLOGY 1987;37:685
© 1987 American Academy of Neurology

Risk factors for Guillain-Barré syndrome

R. A. Kaslow, MD, MPH, J. Z. Sullivan-Bolyai, MD, R. C. Holman, MS, B. Hafkin, MD, R. C. Dicker, MD and L. B. Schonberger, MD, MPH

Chronic Diseases Division, Center for Environmental Health (Dr. Kaslow), and the Division of Viral Diseases, Center for Infectious Diseases (Drs. Sullivan-Bolyai, Hafkin, and Schonberger, and Mr. Holman and Dicker [Epidemiology Elective Student]), Centers for Disease Control, Atlanta, GA.

In 100 cases of Guillain-Barré syndrome (GBS) reported from 10 metropolitan areas to the Centers for Disease Control (CDC) after the 1976-77 influenza vaccination campaign and matched associate or spouse controls, we searched for risk factors for GBS other than A/New Jersey/1976 influenza vaccination and acute respiratory infection. The 47 vaccinated cases recalled influenza vaccination in past years less frequently than did controls (p < 0.025). Cases and controls did not differ in the number of previous vaccinations or in interval from last vaccination, Cases also gave a history of allergy less frequently than controls. There were no other significant differences.

Address correspondence to Dr. Kaslow, Chief, Epidemiology and Biometry Section, National Institute of Allergy and Infectious Diseases, Westwood 739, Nationai Institutes of Health, Bethesda, MD 20205. Address reprint requests to Dr. Schonberger. Division of Viral Diseases, Centers for Disease Control, Atlanta, GA 30333.

Received June 26, 1985. Accepted for publication in final form August 5, 1986.






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