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NEUROLOGY 1987;37:693
© 1987 American Academy of Neurology

Clinical and Sleep laboratory study of narcoleptic symptoms in multiple sclerosis

G. Poirier, MSc, J. Montplaisir, MD, M. Dumont, MPs, P. Duquette, MD, F. Dbcary, MD, J. Pleines, MSc and G. Lamoureux, MD

Centre d'Étude du Sommeil (Mr. Poirier, Dr. Montplaisir, and Ms. Dumont), Hôpital du Sacré-Coeur, and the Hôpital Notre-Dame (Dr. Duquette and Ms. Pleines), Montréal, Québec; the Croix-Rouge Canadienne (Dr. Décary), Ottawa, Ontario; and the Institut Armand Frappier (Dr. Lamoureux), Laval, Queéec, Canada.

Seventy white patients with a diagnosis of MS and typed for their HLA-A, B, C, and DR were studied. A clinical interview and a questionnaire were used to evaluate the presence of narcoleptic symptoms. The prevalence of sleep attacks, cataplexy, and sleep paralysis was significantly elevated among these patients. However, no difference was seen between DR2 and non-DR2 subjects with regard to the incidence of narcoleptic symptoms. Nine DR2 patients complaining of both sleep attacks and cataplexy were studied in the sleep laboratory for five consecutive naps, but no polygraphic evidence of narcolepsy was found.

Address correspondence and reprint requests to Dr. Montplaisir, Centre d'Étude du Sommeil, Hôpital du Sacré-Coeur, 5400 Gouin Blvd, O., Montréal, Québec, H4J 1C5 Canada.

Received May 9, 1986. Accepted for publication in final form August 5, 1986.




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