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NEUROLOGY 1987;37:706
© 1987 American Academy of Neurology

Testosterone levels in adult male epileptic patients

E. Rodin, MD, M. G. Subramanian, PhD, S. Schmaltz, MPH and J. Gilroy, MD

From Wayne State University, School of Medicine (Drs. Rodin, Subramanian, and Gilroy), Detroit, MI; and the University of Michigan (Mr. Schmaltz), Ann Arbor, MI.

Total and free testosterone levels were assayed in 80 epileptic outpatients. The levels were in the low-normal range, and there was no dissociation between free and total levels observable in this sample. No relationships to clinical epilepsy parameters or anticonvulsant levels were found, but significant inverse relationships existed with age and the number of different anticonvulsant medications a patient was taking. The age effect was independent of the medication contribution and raises the question of premature aging of the sexual system in patients with epilepsy. Whether or not this is part of a more general premature decrease in the functions of the pituitary hypothalamic axis needs to be investigated.

Address correspondence and reprint requests to Dr. Rodin, Epilepsy Center of Michigan, 3800 Woodward, Suite 700, Detroit, MI 48201.

Received June 30, 1986. Accepted for publication in final form August 7, 1986.




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Arch Neurol, June 1, 1990; 47(6): 670 - 676.
[Abstract] [PDF]


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