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Hormones and handedness

Left-hand bias in female congenital adrenal hyperplasia patients

New York Hospital-Comell Medical Center, Departments of Pediatrics (Dr. Nass, Ms. Baker, and Drs. Speiser and New) and Neurology (Dr. Nass), New York, NY; Instituto di Clinica Pediatrica, Universitá degli Studi di Parma (Dr. Virdis); Clinica Pediatrica dell'Univenritá, Bologna (Drs. Balsamo and cacciari); Universitá di Cagliari (Dr. Loche), Sardinia, Italy; and Klinika za Djecje, Bolesti Rebro (Dr Dumic), Zagreb, Yugoslavia.

An excess of left-handers among males has been attributed to early androgen exposure. This theory was supported by our observation that girls with congenital adrenal hyperplasia (CAH) are more left-biased than their normal sisters. Male CAH patients, with prenatal androgen exposure similar to that of unaffected brothers, had typical male-handedness patterns.

Address correspondence and reprint requests to Dr. Nass, Department of Pediatrics, New York Hospital, 525 East 68th Street, New York, NY 10021.

Supported in part by a Rockefeller Brothers Clinical Scholarship, a grant from United Cerebral Palsy, and an award from the Rita G. Rude1 Foundation to Ruth Nass.

Presented in part at the Child Neurology Society meeting, Memphis, TN, October 1985.

Received May 30, 1986. Accepted for publication in final form August 4, 1986.

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