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NEUROLOGY 1987;37:717
© 1987 American Academy of Neurology

Amyotrophic lateral sclerosis and history of skeletal fracture

A case-control study Louise S. Gresham, MPH, Craig A. Molgaard, PhD, MPH, Amanda L. Golbeck, PhD and Richard Smith, MD

Division of Epidemiology and Biostatistics (Ms. Gresham and Dr. Molgaard), Graduate School of Public Health, and the Department of Mathematical Sciences (Dr. Golbeck), San Diego State University; and the Center for Neurologic Study (Dr. Smith), San Diego, CA.

A retrospective case-control study was conducted, using 66 amyotrophic lateral sclerosis (ALS) patients and 66 closely matched controls. Cases were ascertained primarily through a neurology clinic. A self-administered questionnaire probed for history of skeletal fractures. Using McNemar's test, no association was found between history of skeletal fracture and pathogenesis of ALS. No predilection for the head, neck, or spine was demonstrated. The extremities accounted for most fracture sites in cases and controls. Among cases, 68% of the fractures occurred before diagnosis, 58% occurring more than 10 years before diagnosis of ALS.

Address correspondence and reprint requests to Ms. Gresham, Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, San Diego, CA 92182.

Received April 28, 1986. Accepteh for publication in final form August 5, 1986.




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