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Serial analysis of peripheral blood T-cell phenotypes and myelin basic protein reactivity in experimental allergic encephalomyelitis

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

We have serially analyzed peripheral blood T-cell phenotypes and reactivity to myelin basic protein (MBP) during the course of acute experimental allergic encephalomyelitis (EAE) in the Lewis rat and have correlated changes with the onset of clinical disease. A reduction in total T cells (W3/13 +), due primarily to a reduced helper/inducer (W3/25 +) subpopulation, preceded the onset of EAE. Circulating MBP-reactive lymphocytes were only transiently present in the blood at the time EAE was clinically evident. Our findings demonstrate that in EAE, immunologic abnormalities in the peripheral blood are transient and can begin before clinical disease is evident.

Address correspondence and reprint requests to Dr. Fallis, Room 5B16, Building 10, National Institutes of Health, Bethesda, MD 20892.

Supported by a grant from the E.I. DuPont de Nemours Company and NIH grant NS169980. Robert J. Fallis was a fellow of the National Multiple Sclerosis Society.

Received February 20, 1986. Accepted for publication in final form August 5, 1986.

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