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NEUROLOGY 1987;37:754
© 1987 American Academy of Neurology

Neuropathologic and clinical features of Parkinson's disease in Alzheimer's disease patients

Susan M. Ditter, MD and Suzanne S. Mirra, MD

Departments of Neurology and Community Health (Dr. Ditter), and Pathology and Laboratory Medicine, Emory University School of Medicine, and Veterans Administration Medical Center (Dr. Mirra), Atlanta, GA.

While dementia in Parkinson's disease (PD) is well described, PD features in Alzheimer's disease (AD) are being increasingly recognized. In 20 neuropathologically confirmed AD brains, 11 cases (55%) showed PD changes (Lewy body formation, neuronal loss, and gliosis of pigmented nuclei), with no significant difference in age or symptom duration between those cases with and without PD pathology. A history of rigidity in the absence of neuroleptic medication was noted in 80% of those with PD pathology but only 14% of those without PD pathology. Tremor was not observed in either group. This suggests that extrapyramidal signs, especially rigidity, noted in many AD patients are related to coexistent PD pathology.

Address correspondence and reprint requests to Dr. Mirra, Veterans Administration Medical Center, 1670 Clairmont Road, Decatur, GA 30033.

Supported by Veterans Administration Merit Award N5747-004 to S.S.M.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received June 3, 1986. Accepted for publication in final form August 12, 1986.




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