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Catecholaminergic activity in idiopathic torsion dystonia

Departments of Neurology and Pediatrics (Dr. Menkes) and Psychiatry (Drs. Wetterberg and Yuwiler), UCLA, Los Angeles, CA and the Department of Psychiatry (Drs. Wetterberg and Ross), Karolinska Institute at St. Goran's Hospital, Stockholm, Sweden.

Day and nighttime melatonin and dopamine-P-hydroxylase activity were measured in blood from 10 Jewish and 9 non-Jewish dystonics and from 22 nondystonic family members. Groups did not significantly differ on either of these measures. These results do not support a generalized abnormality of noradrenergic release in dystonia.

Address correspondence and reprint requests to Dr. Menkes, Department of Neurology, UCLA Medical School, 760 Westwood Plaza, Los Angeles, CA 90024.

Supported by a grant from the Dystonia Medical Research Foundation, the Swedish Medical Research Council grant 3371, and the Veterans Administration Research Service.

Received May 13, 1986. Accepted for publication in final form August 27, 1986.