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NEUROLOGY 1987;37:784
© 1987 American Academy of Neurology

Implicit learning in patients with probable Alzheimer's disease

David S. Knopman, MD and Mary Jo Nissen, PhD

Departments of Neurology and Psychology, University of Minnesota, Minneapolis, MN.

The purpose of the present study was to determine whether patients with probable Alzheimer's disease (AD) were capable of implicit procedural learning. AD patients and elderly control subjects were given a serial visual reaction time task with an embedded repeating sequence. The AD patients responded more slowly than the controls, but many nonetheless showed learning of the repeating sequence. Patients who failed to learn the sequence were similar in age and overall severity of dementia to those who learned, but they scored lower on some tasks of nonverbal reasoning.

Address correspondence and reprint requests to Dr. Knopman, Department of Neurology, Box 295, University of Minnesota Hospitals, Minneapolis, MN 55455.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received June 6, 1986. Accepted for publication in final form August 27, 1986.




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