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Neurochemical dissociation of memory systems

Departments of Psychology (Dr. Nissen) and Neurology (Dr. Knopman), Univenity of Minnesota, Minneapolis, MN and the Department of Psychology (Dr. Schacter), University of Toronto, Toronto, Ontario, Canada.

The administration of scopolamine, an anticholinergic drug, reduced the ability to recall and recognize stimuli presented previously—abilities thought to require declarative memory. In contrast, measures of procedural memory were unaffected by scopolamine: performance on a serial reaction time task incorporating a repeating stimulus and response sequence showed no difference in acquisition and retention of the sequence after scopolamine or saline. These results suggest that the cholinergic system is required for declarative but not procedural memory.

Address correspondence and reprint requests to Dr. Nissen, Department of Psychology, N218 Elliott Hall, University of Minnesota, Minneapolis, MN 55455.

Supported in part by the Center for Research in Human Learning of the University of Minnesota and by a Faculty Research Fellowship (M.J.N.) from the University of Minnesota.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received June 10, 1986. Accepted for publication in final form August 27, 1986.

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