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The potential beneficial effect of nicardipine in a rat model of transient forebrain ischemia

Department of Pharmacology, Syntex Research Centre, Heriot-Watt University, Riccarton, Edinburgh, Scotland; and the Department of Neurology, New York School of Medicine, New York, NY.

In a rat 3-day survival model of 10-minute four-vessel occlusion, halothane anesthesia was used to attenuate the ictal blood pressure elevation of the cerebral ischemic response and thereby maintain an isoelectric EEG. Selectively vulnerable regions of the brain were protected by preischemia plus postischemia maintenance treatment with the calcium entry blocker nicardipine. Compared with untreated animals, repeated doses at 500 µg/kg IP were markedly more effective than doses of 50 µg/kg. Ongoing studies demonstrate a neurocytoprotective action of nicardipine when deferred treatment is given postischemia.

Address correspondence and reprint requests to Dr. Alps, Department of Pharmacology, Syntex Research Centre, Heriot-Watt University, Riccarton, Edinburgh, Scotland EH1 44A.

Presented in part at the thirty-aeventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Received February 24, 1986. Accepted for publication in final form September 5, 1986.

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