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NEUROLOGY 1987;37:832
© 1987 American Academy of Neurology

Parkinson's disease and myasthenia gravis

Adverse effect of trihexyphenidyl on neuromuscular transmission

S. Ueno, MD, M. Takahashi, MD, K. Kajiyama, MD, N. Okahisa, MD, T. Hazama, MD, S. Yorifuji, MD and S. Tarui, MD

Second Department of Internal Medicine, Osaka University Medical School, Osaka, Japan.

A 55-year-old man with idiopathic Parkinson's disease developed myasthenia gravis shortly after taking trihexyphenidyl. The myasthenic weakness waxed and waned with rise and fall in serum levels of trihexyphenidyl, without marked change of anti-acetylcholine receptor antibody titer.

Address correspondence and reprint requests to Dr. Ueno, The Second Department of Internal Medicine, Osaka University Medical School, Fukushima, 1–1–50 Fukushima-ku, Osaka 553. Japan.

Supported in part by a grant from the Neuroimmunological Diseases Research Committee of the Ministry of Health and Welfare of Japan.

Received June 24, 1986. Accepted for publication in final form September 5, 1986.




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Arch Intern Med, February 24, 1997; 157(4): 399 - 408.
[Abstract] [PDF]


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