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NEUROLOGY 1987;37:834
© 1987 American Academy of Neurology

Regional nerve injury after intra-arterial chemotherapy

A. M. Castellanos, MD, J. Peter Glass, MD and W. K. Alfred Yung, MD

Department of New-Oncology, The University of Texaa System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX.

Eleven patients at M.D. Anderson Hospital were referred for neurologic evaluation after having their internal or external iliac arteries catheterized for the treatment of localized pelvic or lower extremity tumors. Nine patients developed lumbosacral plexopathies and two patients, mononeuropathies. All symptoms occurred within 48 hours of the intra-arterial infusion. All patients received cis-dichlorodiammine-platinum (cisplatin; CDDP) intra-arterially, alone or in combination with other agents. Follow-up examinations revealed that only one patient had made partial recovery from the neurologic dysfunction. Chemotherapy-induced small vessel injury, with subsequent plexus or nerve infarction, appears to be the most likely cause, although a direct neurotoxic effect of CDDP cannot be excluded.

Address- correspondence and reprint requests to Dr. Castellanos, Department of Neuro-Oncology, M.D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Box 118, Houston, TX 77030.

Received May 28, 1986. Accepted for publication in final form August 12, 1986.




This article has been cited by other articles:


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 J. Neurol. Neurosurg. PsychiatryHome page
W. A Wohlgemuth, K. G Rottach, and M Stoehr
Intermittent claudication due to ischaemia of the lumbosacral plexus
J. Neurol. Neurosurg. Psychiatry, December 1, 1999; 67(6): 793 - 795.
[Abstract] [Full Text] [PDF]


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